ECRI-Penn Medicine Evidence-based Practice Center
Transforming research into actionable insights that improve healthcare quality and outcomes.
Advance clinical practice through systematic evidence review.
The ECRI-Penn Medicine EPC Program stands at the forefront of advancing healthcare quality and evidence-based medicine. By focusing on the systematic review, evidence synthesis, and guideline development, this collaboration ensures healthcare practices are informed by the most current and relevant evidence available.
Learn about ECRI’s extensive health technology assessment capabilities.
The ECRI-Penn Medicine EPC provides a full service approach to systematic evidence review. Our in-depth assessments meticulously synthesize clinical studies, guidelines, and gray literature to provide actionable results. This process is anchored by our qualitative GRADE strength of evidence and risk of bias assessments, and leverages ECRI's extensive methodology expertise alongside Penn Medicine's deep clinical knowledge. Our capabilities include systematic review, methodology support, grading of evidence, risk of bias assessment, guideline recommendations, and methods training.
1/1
Nation's only organization designated as both an Evidence-based Practice Center (EPC) and Patient Safety Organization (PSO)
1 of 9
Agency for Healthcare Research and Quality (AHRQ) designated Evidence-Based Practice Centers in the U.S.
Inform clinical practice guideline development.
We synthesize the best available evidence into practical insights, to help medical societies and healthcare organizations develop evidence-based practice guidelines and policies. ECRI’s systematic process ensures healthcare delivery is both efficient and aligned with the latest scientific evidence, improving patient outcomes and shaping the future of healthcare policy.
Recent Projects
AHRQ Comparative Effectiveness Review
Impact of Healthcare Algorithms on Racial and Ethnic Disparities in Health and Healthcare
Our objective was to examine the evidence on whether and how healthcare algorithms (including algorithm-informed decision tools) exacerbate, perpetuate, or reduce racial and ethnic disparities in access to healthcare, quality of care, and health outcomes, and examine strategies that mitigate racial and ethnic bias in the development and use of algorithms.
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AHRQ Rapid Evidence Review
Reducing Adverse Drug Events Related to Anticoagulant Use in Adults
Our objective was to summarize the most relevant and recent literature on interventions to support safe care transitions and continuation of anticoagulants post-discharge, and anticoagulation management services in ambulatory settings.
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VA Guideline Development
Management of Posttraumatic Stress Disorder and Acute Stress Disorder
Our objective was to help the Veteran’s Administration improve patient outcomes and local management of patients with Posttraumatic Stress Disorder and Acute Stress Disorder by providing evidence-based findings to inform new and updated recommendations and practices for practitioners throughout the DoD and VA Health Care systems.
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PCORI Emerging Technologies and Therapeutics Report
Genomic Sequencing to Guide Cancer Management
Our objective was to summarize the current state of clinical evidence supporting use of next-generation sequencing (NGS)-based genomic testing for guiding management of patients with cancer for the Patient-Centered Outcomes Research Institute (PCORI).
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ACR Guideline Development
Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases
Our objective was to help the American College of Rheumatology update their guideline with expanded indications for some vaccines in patients with rheumatic and musculoskeletal diseases, and guidance about holding immunosuppressive medications or delaying vaccination to maximize vaccine immunogenicity and efficacy.
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AUA Guideline Development
Surgical Treatment of Female Stress Urinary Incontinence
Our objective was to help the American Urological Association update their clinical practice guideline on stress urinary incontinence to include the newest and most pertinent clinical literature and to update their treatment algorithm to reflect current treatment techniques and associated data.
Learn moreResearch Staff
10
PhD-level methods experts
12
Master-level public health research experts
8
Master-level medical librarians
2
PhD-level biostatisticians
200+
Clinicians and SMEs
including infection preventionists, biomedical engineers, physicians, pharmacists, and nurses
10+
Support positions
(e.g., project managers, medical editors, bibliographic specialists)
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More Ways We Help
Patient Safety Organization
Build a culture of safety with patient safety expertise, guidance, data, and broad subject matter knowledge.
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Clinical Evidence
Enhance insights and decisions on new, emerging, and existing technologies with independent evidence analysis.
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Horizon Scanning
Keep up with new and emerging technologies, procedures, and treatment models to help define the future of healthcare.
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