
Clinically Informed Human Factors Engineering
Designing safer systems, reducing harm, and empowering clinicians
Staff burnout, technology challenges, and inefficiencies create hidden risks that put both patients and clinicians in danger. The question isn’t whether safety improvements are needed—it’s how to make them achievable and lasting.

A System-Based Approach
ECRI’s team of highly skilled human factors engineers, or safety scientists, focuses on how people interact with tools, technologies, processes, and environments within healthcare systems. We specialize in identifying barriers to healthcare quality and safety and developing tailored solutions that improve workflows, enhance technology integration, minimize risks, and support healthcare professionals in delivering safer, more effective care. By designing systems that support the workforce, we reduce inefficiencies, strengthen patient safety, and drive better outcomes.
The Hidden Costs of Ineffective Safety Systems
$20B
lost annually to preventable medical errors
(Source: National Library of Medicine)
82%
of nurses identified fatigue as a contributing factor to medication errors and near misses
(Source: Stanford Medicine)
40%
of clinicians waste time on operational inefficiencies
(Source: NetSec.news)
Designing Safer, Smarter Systems
Human factors engineering (HFE) is an applied science that combines psychology and engineering. It transforms complex work systems to enhance safety, effectiveness, efficiency, and satisfaction.
Challenges We Solve
HFE ensures that people, processes, and technology work together seamlessly for safer, more efficient care.
- Preventing Harm – Designing systems that eliminate errors before they occur
- Reducing Cognitive Load – Minimizing distractions, alert fatigue, and information overload
- Enhancing Technology Usability – Improving integration of electronic health records, medical devices, and automation for clinicians
- Improving Teamwork & Communication – Strengthening handoffs and reducing miscommunication
- Creating Safer Workflows – Eliminating
inefficiencies and high-risk workarounds


Impact Story
Health System Reduced Sepsis Mortality by 25% through HFE
Challenge: A multistate nonprofit health system faced rising sepsis mortality rates, with the Severe Sepsis/Septic Shock Mortality Index increasing.
Approach: ECRI human factors engineers identified key usability issues and systemic inefficiencies, leading to workflow modifications.
Results: 25% reduction in sepsis mortality since 2021, 700 lives saved through improved detection and treatment, and $30 million in cost savings from optimized workflows and reduced hospital stays
HFE System Analysis℠ Solutions include:
Proactive Safety and System Design
- Workflow and facility design to reduce risk
- Usability testing and simulation-based assessments
- Staff preparation through scenario-based simulations and product testing
- Device selection improvement with human factors evaluation
Event Analysis and Harm Prevention
- Root cause analysis and forensic safety reviews
- Targeted interventions for high-risk processes
- Analysis of near misses that uncovers underlying causes of safety incidents and implements targeted improvements
Why Work with Us
Learn More: Human Factors Engineering 101
Want to understand the fundamentals of HFE and how it transforms patient safety?

Let’s Build a Safer Future Together
Take the first step.
Connect with our team today to discuss your challenges and how HFE solutions can help.

Patient Safety Advisory Services
Tackle healthcare's most pressing challenges head on with our human-centered, systems-based approach.
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Patient Safety Organization
Build a culture of safety with patient safety expertise, guidance, data, and broad subject matter knowledge.
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Clinical Evidence Assessment
Enhance insights and decisions on new, emerging, and existing technologies with independent evidence analysis.
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Infection Prevention and Control Consulting Services
Prevent healthcare-associated infection risks through collaboration, analysis, and total systems improvement.
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Healthcare Incident Investigation and Technology Consulting
Conduct scientific clinical incident investigations with independent technology experts.
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